Elevated atherogenic index of plasma is associated with severe acute kidney injury in critically ill patients with cardiovascular disease - a MIMIC-IV analysis with external validation in the eICU-CRD database.

Q1) were significantly associated with stage 3 AKI and RRT, with highly significant trends observed across quartiles ( P for trend = 0.005 and 0.002, respectively), reinforcing the validity of the AIP as a prognostic marker ( Supplementary Table S5 ).

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While the trend analysis for categorical AIP showed marginal significance ( P for trend = 0.071 for stage 3 AKI, P for trend = 0.077 for RRT), likely because the strict weighting process reduced the effective sample size, the direction of association remained consistent.

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