INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice.

Front Med (Lausanne) · 2026 · PMC13288762 · PMID 42344483

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a decreasing trendno p-value reported

INVA8001 attenuated the expression of Fcer1a and Mcpt1 in the liver samples from Mdr2 −/− mice; however, the expression of Tpsb2 showed a decreasing trend (not statistically significant) ( Figure 3B ).

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