The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence.

Addict Biol · 2026 · PMC13290382 · PMID 42337660

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an increasing trendno p-value reported

Our research indicated that compared with pseudo stress, adolescent mice exposed to acute stress before alcohol‐induced CPP reinstatement showed significantly higher orexin levels in the mPFC, Hip and NAc, and there was an increasing trend in orexin levels in the VTA.

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