Unveiling the efficacy predictors and potential mechanisms of <i>Semen Cuscutae</i> against osteoporosis via machine learning and meta-analysis: a preclinical study.

Front Immunol · 2026 · PMC13290541 · PMID 42358988

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an increasing trendno p-value reported

Mechanistically, Semen Cuscutae remodeled the osteoimmune microenvironment by suppressing pro-inflammatory cytokines (IL-6) and bone resorption markers (TRACP, CTX, RANKL), while ALP showed an increasing trend and osteogenic or reparative factors, including OPG, IGF, and TGF-β, were significantly upregulated.

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Unveiling the efficacy predictors and potential mechanisms of &lt;i&gt;Semen Cuscutae&lt;/i&gt; against osteoporosis via machine learning and meta-analysis: a preclinical study.

The sentences

Unveiling the efficacy predictors and potential mechanisms of <i>Semen Cuscutae</i> against osteoporosis via machine learning and meta-analysis: a preclinical study.