highly significantP -value < 0.001
VEGF A & TGF β1 measured in arbitrary units (AU): Both growth factors showed highly significant scores in the CTG immersed in i-PRF analyzed in the CTG + i-PRF group, compared to the CTG alone from the CTG group ( P -value < 0.001), with large effect sizes for both growth factors suggesting a substantial magnitude of difference in growth factors expression between groups ( Table 5 ).