Low-Dose Naltrexone: What is the Evidence? A Narrative Review.

Adv Ther · 2026 · PMC13290944 · PMID 42060160

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approached but did not reach significanceno p-value reported

In an interventional pre-post study ( n = 52), 2 months of LDN (1–3 mg/day) was associated with significant improvements in self-reported recovery, activities of daily living, energy, pain, concentration and sleep, while mood improvement approached but did not reach significance [ 66 ].

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