Systematic review of environmental factors associated with severe fever with thrombocytopenia syndrome occurrences.

Of these, 15 accounted for potential nonlinearity in the relationship: 8 reported a reverse-U-shaped relationship (defined as a pattern in which risk increases up to an optimal level followed by a subsequent decline), 15-18 , 21 , 27-29 4 observed an increasing trend, 22 , 24-26 2 identified a decreasing trend, 13 , 20 and 1 reported a pattern of consistent risk followed by a sharp decline at higher temperature. 30 Among studies reporting a reverse-U-shape, the high-risk range varied depending on both temporal (annual vs monthly) and spatial (nationwide vs subnational) measurement scales.

also in 47,180 other papers