ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma pathogenesis.

Nucleic Acids Res · 2026 · PMC13291608 · PMID 42339622

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a nonsignificant trendno p-value reported

We also noted increased WNT5A expression in IDH-mutant, ATRX-deficient gliomas (astrocytomas) compared to IDH-mutant, ATRX-intact gliomas (oligodendrogliomas) in transcriptional data from the TCGA and the CGGA, with a nonsignificant trend to higher expression also seen in transcriptional data from the GLASS Consortium ( Supplementary Fig.

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