Hemoperfusion with a polymer-based column alters inflammatory responses in lipopolysaccharide-treated horses in vivo.

Because the column used in this study works through a gradient removal mechanism, horses with a more profound cytokine response demonstrated greater removal compared to horses with a marginal cytokine response, which could have resulted in our data having a nonsignificant trend. 23 Another factor could be the need for further optimization of a hemoperfusion prescription 24 that is specific for an individual animal and is guided by examination and/or biomarker parameters, such as cytokines or markers of neutrophil activation.

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