Bone Mineral Density Loss in Relapsing-remitting Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Matched Case-control Study

International Journal of Preventive Medicine · 2026 · PMC13293545

Europe PMC

hedged sentences

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closest p · 1.5× alpha

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boldest claim

The sentences

marginally significantP value = 0.075so close (0.05 < p ≤ 0.1)

The probability of BMD loss exhibited marginally significant relationships with disease duration (OR = 1.1, 95% CI: 1 to 1.3, P value = 0.075), serum level of calcium (OR = 0.1, 95% CI: 0 to 1.4, P value = 0.085) and phosphorus (OR = 0.1, 95% CI: 0 to 1.2, P value = 0.072), vitamin D3 (OR = 1, 95% CI: 0.9 to 1, P value = 0.088), and sleep disorders (OR = 4.4, 95% CI: 0.8 to 4.6, P value = 0.088) in RRMS.

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a possible trendno p-value reported

For NMOSD patients, age, EDSS, physical activity, ALP, vitamin D3, and phosphorus levels exhibited significant relationships, while BMI showed a possible trend.

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