Inaccurate interpretation of hypoxia signatures from transcriptomic analyses in neuro-oncology.

Neoplasia · 2026 · PMC13293650 · PMID 42308836

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an increasing trendno p-value reported

We have noticed an increasing trend of taking the names of gene sets at face value without critically examining them for accuracy, biological relevance and the experimental conditions used to derive them.

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highly significantno p-value reported

We want to bring the attention to a few genes that are highly significant to the neuro oncology field and that are included in the HALLMARK_HYPOXIA signature. • EGFR (epidermal growth factor receptor).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.