Sequential CRISPR-EspCas9-Mediated Wild-Type Depletion Enhances the Detection Sensitivity of Rare Mutations for Canine Liquid Biopsy Application.

Biosensors (Basel) · 2026 · PMC13296737 · PMID 42345886

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a decreasing trendno p-value reported

For KRAS G12C at 0.1% input, OR values against round-matched 0% controls were 13.2 (1st), 6.3 (2nd), and 3.2 (3rd round), showing a decreasing trend across sequential IVC rounds.

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