L-Arginine and Its Metabolites in Age-Related Cerebral Small Vessel Disease with Cognitive Impairment

Biomolecules · 2026 · PMC13297444

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highly significantno p-value reported

Another highly significant factor contributing to NO deficiency is a lack of exogenous L-arginine or the cofactor BH4, which promotes eNOS uncoupling due to the so-called L-arginine paradox [ 13 , 14 ].

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