Tailoring Oncofertility to Breast Cancer Subtype: A Systematic Review of Fertility Preservation Strategies in Premenopausal Women

For example, a randomized controlled trial ( n = 98) reported that the rate of one-year ovarian failure was significantly reduced from 80.6% in the chemotherapy-alone group to 44.7% in the GnRHa group ( p = 0.002), with benefit observed across HR+ and HR− subgroups, though statistical significance was reached only in the HR+ subgroup ( p = 0.029); the HR− subgroup showed a numerical trend that did not reach significance ( p = 0.111) [ 32 ].

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