Efficacy and Safety of Sustained-Release Melatonin Capsules (2 mg) in Healthy Adults with Poor Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.

Clocks Sleep · 2026 · PMC13297780 · PMID 42345841

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a decreasing trendno p-value reported

Change in Sleep Quality Evaluated Using Pittsburgh Sleep Quality Index (PSQI) Subjective assessment of sleep quality demonstrated a decreasing trend in the global PSQI scores from baseline to the end of the study duration (day 28) in both study groups.

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a positive trendno p-value reported

Participants receiving melatonin-SR demonstrated a positive trend of improvement in overall WHO-5 well-being scores across the study duration, with a statistically significant improvement in subjective psychological well-being from day 14 onward (13.91%), sustained through day 28 (18.76%), compared with the placebo group.

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