highly significantp < 0.001
When acting on Avicel ® , mutants E185V/Q108M and E185V/Q108M/A249P exhibited reducing sugar yield of 0.78 g/L and 1.36 g/L, respectively, representing highly significant increases ( p < 0.001) of 27.8% and 122.9% compared to An LPMO15g (0.61 g/L).