Barely Significant
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Molecular Basis of Synergistic Causal Effect of Dual GLP-1R and GIPR Agonists for Risk Reduction in Diabetic Retinopathy, Alzheimer Disease, and Coronary Artery Disease in Diabetic Patients

Genes (Basel) · 2026 · PMC13298441

Europe PMC
1
hedged sentence
0.0720
closest p · 1.4× alpha
0.0720
boldest claim

The sentences

narrowly missed statistical significancep = 0.072so close (0.05 < p ≤ 0.1)
The BMI-mediated effect was non-significant at the GIPR locus (OR = 0.64; 95% CI, 0.27–1.53; p = 0.322) and narrowly missed statistical significance in the combined dual agonism model (OR = 0.56; 95% CI, 0.30–1.05; p = 0.072). 3.3.

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