Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis

Int J Mol Sci · 2026 · PMC13299116

Europe PMC

hedged sentences

0.0010

closest p · 0.0× alpha

0.0956

boldest claim

The sentences

highly significantp = 0.001actually significant

Concurrently, a strong, highly significant positive correlation was identified between local AR tissue density and intracellular lead accumulation (rs = 0.415, p = 0.001), supporting the interplay between heavy metal deposition and receptor presentation.

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a marginal trendp = 0.076so close (0.05 < p ≤ 0.1)

This model was additionally characterized by a marginal trend for DHEA (negative, p = 0.076), whereas estradiol showed no statistically significant association ( p = 0.094) and BMI was excluded from the final equation.

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a positive trendp = 0.0956so close (0.05 < p ≤ 0.1)

Androgen receptor (AR) expression showed a positive trend with the resorption marker CTX-I ( p = 0.0956).

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