Serum β-hCG Combined with Traditional Tumor Markers Improves Detection Efficacy and Prognostic Prediction in Cholangiocarcinoma

Int J Mol Sci · 2026 · PMC13299596

Europe PMC

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highly significantno p-value reported

The network analysis confirmed highly significant biological interactions between LHCGR and the chorionic gonadotropin subunit beta (CGB) protein family (specifically CGB3, CGB5, and CGB8), which encodes the β-subunits of human chorionic gonadotropin (β-hCG) ( Figure 1 D).

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an increasing trendno p-value reported

The transcriptomic analysis confirmed an increasing trend in LHCGR mRNA expression in CCA tumor tissues compared to normal adjacent tissues ( Figure 1 B).

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