Methyl Caffeate Binds to IQGAP1 and Inhibits the Senescence-Associated Secretory Phenotype in Senescent Cells

Int J Mol Sci · 2026 · PMC13299695

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a decreasing trendno p-value reported

IQGAP1 knockdown reduced the secretion and mRNA expression levels of IL-6 and IL-8 , decreased NF-κB activity, and showed a decreasing trend in p38 phosphorylation ( Figure 3 ).

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