Panel-Wide Screening of Tumour Cells of Diverse Histogenesis for Responsiveness to Silencing of miR-21, miR-17, and miR-155 by Mesyl Phosphoramidate Antisense Oligonucleotides

Integration of these data did not reveal a statistically significant correlation between basal levels of miR-21, miR-17, and miR-155 and cellular sensitivity to miRNA-targeted μ-AMOs; however, the data suggested a possible trend where the highest expression of all three miRNAs was observed in U937 cells (lymphoid origin), and lowest expression of all three miRNAs was detected in Raji cells (also of lymphoid origin) and non-transformed fibroblasts hFF3, and these three lines were characterised by low or no sensitivity to μ-AMO treatment. 2.5.3.

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