Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in LPL, APOC2, APOA5, GPIHBP1, LMF1, APOE and Polygenic Risk.

Int J Mol Sci · 2026 · PMC13300099 · PMID 42353159

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borderline significanceno p-value reported

PRS percentiles were higher in FD than in the moderate-to-low PRS group (ΔMe 8, 95% CI: 0−15; p = 0.048), with borderline significance.

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Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in &lt;i&gt;LPL&lt;/i&gt;, &lt;i&gt;APOC2&lt;/i&gt;, &lt;i&gt;APOA5&lt;/i&gt;, &lt;i&gt;GPIHBP1&lt;/i&gt;, &lt;i&gt;LMF1&lt;/i&gt;, &lt;i&gt;APOE&lt;/i&gt; and Polygenic Risk.

The sentences

Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in <i>LPL</i>, <i>APOC2</i>, <i>APOA5</i>, <i>GPIHBP1</i>, <i>LMF1</i>, <i>APOE</i> and Polygenic Risk.