Monocyte-Containing Inflammatory Indices Show Stronger Association with 30-Day Mortality than the Systemic Immune-Inflammation Index in Elderly Sepsis: A Single-Center Retrospective Observational Cohort Study

In a fully saturated model simultaneously including sex, mechanical ventilation and comorbidity count (six predictors for 33 events, well beyond the events-per-variable limit), the AISI effect retained a comparable magnitude (aOR 2.57) but reached only marginal significance (95% CI 0.98–6.72, p = 0.054), an attenuation attributable to over-parameterization rather than to loss of signal, and one that underscores why the pre-specified parsimonious model was the appropriate primary specification.

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