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Comparative Augmentative Efficacy of Second-Generation Antipsychotics in Adult Treatment-Resistant Depression: A Systematic Review.

Cureus · 2026 · PMC13305443 · PMID 42367531

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an encouraging trendno p-value reported
These agents offer a clinically significant reduction in depressive symptoms, with an encouraging trend towards early onset of action.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.