Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.

Alzheimers Dement · 2026 · PMC13309852 · PMID 42363726

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borderline significantno p-value reported

Treatment effect heterogeneity by CKM stage Robust effect modification by CKM stage was observed for the association between intensive BP control and probable dementia risk, which was significant on the HR scale ( p interaction = 0.009) and borderline significant on the ARR scale ( p interaction = 0.053).

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