Multi-omics integration and <i>in vitro</i> validation identify IL4R, IMPA2, and PRR4 as key therapeutic targets in chronic rhinosinusitis with nasal polyps.

MR analysis confirmed that downregulation of PRR4 expression is a risk factor for CRSwNP (OR = 0.99951, P = 0.04280), with the caveat that the very small effect size and borderline significance indicate limited evidence strength at present.

also in 7,017 other papers

MR analysis preliminarily suggested that IL4R and IMPA2 may be potential risk factors for CRSwNP, while PRR4 may serve as a potential protective factor, though the effect sizes were modest (OR values close to 1) and P values were borderline significant (0.043–0.045), indicating limited evidence strength.

also in 11,409 other papers