Transdermal entry of a non-pathogenic filamentous fungus <i>Aspergillus oryzae</i> induces an immunomodulatory response in skin-draining lymph nodes.

IgG antibodies reacting with AoC protein extracts were detected at both 14 and 35 days after AoC treatment alone or in the presence of OVA/alum, showing an increasing trend over time ( Figures 6B, C ).

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In resident DCs, a decreasing trend was also observed at both 1–2 days post-injection, with no significant difference compared to PBS; a significant decrease was detected at 4 days post-injection ( Supplementary Figures 5A, B ).

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