s inferred the developmental trajectory from csCAFs to iCAFs; (3) Spatially resolved analysis revealed the close proximity of csCAFs and iCAFs, with interacting more closely with immune cells in the stroma; (4) During pancreatic carcinogenesis, csCAFs exhibited a declining trend, while iCAFs showed an increasing trend.
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Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics.
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