Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.

Such an imbalance may be a factor triggering a critical cascade: concomitant with oxidative stress, cells appear to activate a self-rescue program, supported by the highly significant compensatory upregulation of GCLM and the cystine/glutamate antiporter SLC7A11 to boost GSH synthesis ( Fig. 7 A and B).

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