Effects of SGLT2I Therapy on Tubular Reabsorption and Tubular Epithelial Stress Injury in Patients With CKD.

Kidney Med · 2026 · PMC13312476 · PMID 42376647

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highly significantno p-value reported

Of importance, after adjustment for all identified confounders, the increase in uα-1-MG during SGLT2I therapy remained highly significant, supporting a direct effect of SGLT2 inhibition on tubular protein handling that appears to be independent of these factors.

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