Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.

Gut Microbes · 2026 · PMC13313184 · PMID 42343156

Europe PMC DOI

hedged sentence

0.0924

closest p · 1.8× alpha

0.0924

boldest claim

The sentences

a statistical trendp = 0.0924so close (0.05 < p ≤ 0.1)

Claudin-5 expression in Muc2 −/− mice decreased in relation to the Muc2 +/+ , although IBA-1 and GFAP were not altered with IBA-1 displaying a statistical trend ( p = 0.0924) only, revealing that while the blood–brain barrier is dysregulated and that there were elevated inflammatory cytokines in the brain, glial activation was evident.

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