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Reply to: How to Interpret the Results in a Noninferiority Randomized Trial in Chronic Lymphocytic Leukemia.

J Clin Oncol · 2026 · PMC13313474 · PMID 42008785

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a favorable trendno p-value reported
However, it should be noted that the investigator-assessed EFS analysis showed a favorable trend for pirtobrutinib compared with ibrutinib across all three populations (Fig 1 ), consistent with EFS by IRC (Fig 2 ) and consistent with the overall efficacy findings reported in the manuscript.

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