Microglial SWELL1 deficiency drives male-specific seizure vulnerability but paradoxical neuroprotection through impaired phagocytosis.

JCI Insight · 2026 · PMC13313489 · PMID 42325092

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a nonsignificant trendno p-value reported

However, females exhibited less neuronal loss than males, with statistically significant protection in SWELL1 cKO mice and a nonsignificant trend in littermate controls.

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