p53 regulates mitochondrial function and alpha-synuclein aggregation in Parkinson's disease.

Meanwhile, after inhibiting p53 expression, the protein levels of Drp1 and Fis1 in the P + M group were significantly lower than those in the MPP + group, Opa1 was higher, and Mfn2 showed an increasing trend, which suggests that inhibition of p53 expression to some extent reduces the excessive mitochondrial fission and increases mitochondrial fusion in the pathology of PD.

also in 63,971 other papers

The expression of apoptotic proteins Bax and Caspase3 increased after MPP + treatment, while anti-apoptotic protein Bcl-2 showed a decreasing trend in expression.

also in 47,180 other papers