Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R-mediated activation of autophagy through AKT/mTOR inhibition.

J Orthop Translat · 2026 · PMC13316188 · PMID 42381999

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a decreasing trendno p-value reported

IHC similarly revealed significantly lower p-AKT levels in articular cartilage tissue from semaglutide-treated mice compared to DMM controls, with a decreasing trend in p-mTOR expression ( Fig. 5 G and H).

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