AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways.

PLoS One · 2026 · PMC13318055 · PMID 42378305

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closest p

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highly significantno p-value reported

The enrichment p values for VEGFR1 (p = 0.000324) and the Endothelin 1 receptor (p = 0.000385) were both highly significant, confirming that the observed interactions are biologically meaningful rather than occurring by random association.

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