Impaired keratinization activity in perianal Crohn's fistulas is associated with poor prognosis.

Analysis of specific markers that characterized the 3 tissue subtypes in our DSP analyses ( Figure 3C , left) showed a strong increase of intermediate transcripts MMP7 and WFDC2 and a moderate increase in squamous tissue associated transcripts CALML5 and KRT13 although the last failed to reach significance ( Figure 3C , right).

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