Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

The correlation between Kat5 cKO DEGs and the comparative AD datasets was weak but highly significant (Figure 3B ) due to the elevated correlation observed in specific overlapping biological domains (Figure 3C ), most consistently synapse and immune response, with overlap between Kat5 cKO and the human datasets observed in cell cycle and endolysosome domains as well (Figure 3C ).

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