A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.

In the second study, which used the same longitudinal trend analysis approach but used data up to 2022, the authors reported a significant association between HTP use and a decreasing trend of acute coronary syndrome hospitalisations among four subgroups in which HTP use was most prevalent (younger adults, smokers, those residing in Tokyo, and those residing in prefectures with high HTP use).

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These effects were statistically significant (i.e., the 95% CIs did not span 1) for dual users and recent quitters/novel product users, and the upper 95% CI of 1 for the cohort of longer‐term quitters/novel product users suggests an effect close to significance.

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