Macrophage-Specific SPP1 Contributes to Pressure Overload-Induced Cardiac Dysfunction and Maladaptive Remodeling.

JACC Basic Transl Sci · 2026 · PMC13321008 · PMID 42361615

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an increasing trendno p-value reported

To further explore the heterogeneity of these monocytes/macrophages, we reclustered them into 6 distinct subtypes ( Figure 1C ), among which a subtype of SPP1 + macrophages (cluster 4) showed an increasing trend following TAC (Figures 1D to 1F).

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