highly significantP < 0.0001
While no significant difference was observed at lower concentrations (15.62 μg/mL, 31.25 μg/mL, and 62.5 μg/mL) compared to the control, a marked inhibitory effect emerged at 125 μg/mL ( P = 0.005) and became highly significant at 250 μg/mL, 500 μg/mL, and 1000 μg/mL ( P < 0.0001).