Transarterial Chemoembolization plus Systemic Therapy versus Transarterial Chemoembolization alone for Unresectable, Nonmetastatic Hepatocellular Carcinoma: Meta-Analysis and Trial Sequential Analysis from Randomized Controlled Trials.

Liver Cancer · 2026 · PMC13322702 · PMID 42388346

Europe PMC DOI

hedged sentence

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

borderline significantp = 0.05actually significant

When these MVI-inclusive cohorts were added to the pooled analysis, the OS advantage of the combination therapy was attenuated and became borderline significant (HR = 0.90, p = 0.05).

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