Targeting RAC1 in glioblastoma: prognostic value, immune landscape, and small molecule therapeutic potential.

Front Oncol · 2026 · PMC13322918 · PMID 42394691

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

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boldest claim

The sentences

did not achieve significanceP > 0.05actually significant

The remaining seven Lasso-selected genes (RAC2, RAC3, RHOB, RND1, RND2, RND3, RHOD) did not achieve significance in multivariate analysis (all P > 0.05).

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failed to reach significanceno p-value reported

Subsequent multivariate Cox analysis confirmed RAC1 as the sole family member with an independent hazard ratio exceeding 2 (HR = 2.61, 95% CI: 1.39-4.88, P = 0.003), while other selected genes such as RAC2, RAC3, RHOB, and RND1–3 failed to reach significance.

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