ARHGAP39 plays an essential role in anxiety-like behavior and stress response.

However, we found an increasing trend of Cofilin-1 and Arp3 in Arhgap39 cKO compared to WT mice (Fig. 4f ), indicating morphological changes of the synapse.

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In anxiety tests, aged Arhgap39 cKO mice displayed a nonsignificant trend toward increased anxiety, showing a tendency to spend less time in the center area of the open field and in the open arms of the elevated-O-maze (Fig. 3a, b ).

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