Barely Significant
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Rigorous Modeling and Industrial-Scalable Optimization of Hydroquinone-Catechol Vacuum Distillation: Aspen Plus-RSM Integration for Thermally Labile Systems.

ACS Omega · 2026 · PMC13325387 · PMID 42395972

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highly significantP < 0.0001actually significant
, For example, the elongated contours in Figure highlight a strong synergistic effect between reflux ratio and feed tray location on hydroquinone purity, consistent with ANOVA results identifying the X 1 X 3 interaction term as highly significant ( P < 0.0001).

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