Neural biomarkers in pulpitis and their associations with inflammation and pain perception: a systematic review and meta-analysis.

The result revealed a marginally significant pooled effect size (Hedges’ g = 3.108, 95% CI: 0.008 to 6.208, p = 0.050), with substantial heterogeneity (I2 = 87.3%, Q = 37.291, p < 0.001), although all included studies reported statistically significant higher expression of SP in teeth with symptomatic irreversible pulpitis compared to healthy controls.

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