Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy.

Interestingly, however, there was a highly significant correlation in expression between GRM4 and GRM8 , particularly in the control samples (linear regression, R 2 = 0.7352, F = 27.77, ***p = 0.0004; Fig. 3C ) that was also present in the RTT cohort (**p = 0.0027, Fig. 3D ).

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In our previous report ( Gogliotti et al., 2017 ), we did not achieve significance in mRNA reduction in the subset of RTT patients examined; therefore, this current work provides the first evidence in humans that mGlu 7 levels are reduced at the level of transcription or mRNA stabilization in RTT patients.

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