Barely Significant
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Beyond motor neurons: peripheral TDP-43 pathology in skeletal muscle and intramuscular nerves in amyotrophic lateral sclerosis.

Brain Commun · 2026 · PMC13332408 · PMID 42404433

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highly significantP < 0.0001actually significant
Among the 57 ALS and 23 non-ALS patients with evaluable specimens, axonal pTDP-43 was observed in 98.2% of ALS subjects (56 of 57) versus 30.4% of non-ALS subjects (7 of 23), a highly significant difference ( P < 0.0001).

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