Although a decreasing trend was observed, DCZ did not significantly rescue the increase in percent/amount of chow intake or decreased HFD preference seen with Ex-4 ( Figure 6 D, S6B ).
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In contrast, DCZ pretreatment of the hM4d group produced a highly significant attenuation of the hypophagic effects of Ex-4 on HFD intake ( Figure 6 C, S6A ).