Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.

Hum Genet · 2026 · PMC13332965 · PMID 42400756

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a weak trendno p-value reported

A weak trend toward reduced attenuation may be present in some cases, although the relationship was neither monotonic nor uniform.

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